ZW25
HER2 x HER2 Bispecific Antibody
Zymeworks’ lead product candidate, ZW25, is a HER2-targeted bispecific antibody developed using Zymeworks proprietary Azymetric™ platform. ZW25 is currently being evaluated in global Phase 1 and Phase 2 clinical trials as a best-in-class treatment for patients with HER2-expressing cancers, including biliary tract, gastroesophageal adenocarcinomas, breast, and other tumor types.
ZW25 simultaneously binds two distinct sites on HER2, a protein expressed on many types of cancer cells. This unique design results in multiple mechanisms of action, including dual HER2 signal blockade, increased antibody binding, receptor clustering, and removal of HER2 from the cell surface, and potent effector function.
ZW25 has been granted two Fast Track designations, one for previously treated or recurrent HER2-positive biliary tract cancer and another for first-line gastroesophageal adenocarcinoma in combination with standard of care chemotherapy, as well as Orphan Drug designation for the treatment of biliary tract, gastric and ovarian cancers.
Azymetric™
ZymeLink™
EFECT™
